Differentiating ACell from PRP in Hair Loss Treatment, and Why a Custom Combination Works Best

Differentiating ACell from PRP in Hair Loss Treatment, and Why a Custom Combination Works Best


Thank you for your question. You’re asking what is the difference between
PRP and Acell for hair restoration treatment. Now you submitted your question without a
photo but I can certainly help you understand how I explain our treatment and a lot of the
nuance in the actual substance of your question. A little bit of background, I’m a Board-certified
cosmetic surgeon and Fellowship-trained oculofacial plastic and reconstructive surgeon. I have
been in practice in Manhattan and Long Island for over 20 years. I am also the founder of
TrichoStem™ Hair Regeneration Centers, a system we developed derived from the use and
experience in using PRP and Acellular matrix going on for over 7 years helping patients
from around the world and arguably amongst the first physicians to use this material.
And we have developed systems based on individual clinical profiles to customize the treatment.
So I want to first give you a little bit of perspective, a little bit of historic perspective. When Acellular matrix was first being employed,
it was being employed for hair transplant surgery. Hair transplant surgery has always
been fraught with two significant challenges: one is maximizing the survivability of hair
grafts. Two was improving the healing of the donor area. A serendipitous consequence of
course like many medical discoveries was that thinning hairs in some patients appeared to
get thicker. Well, what I did was, after seeing that possibility, was that I started to offer
the treatment as a standalone treatment for different types of hair loss. This included
male pattern loss, female pattern hair loss, alopecia areata, scarring alopecia such as
lichen planopilaris, central centrifugal cicatricial alopecia, frontal fibrosing alopecia, alopecia
totalis. Essentially, we were trying to help as many patients as we could with what was
in the beginning a significant impact in the treatment of hair loss. What I have determined over the course of
time and this was an evolution that especially in the early years where very few people were
doing this and there were no clear answers as to the best way to formulate the PRP, to
dose the Acellular matrix, to dose it in individual injections, to get the best way to deliver
the material. Essentially, we were dealing with a lot of unknowns. And to help develop
predictability and consistency, we had to look at our results very critically and document
the responses and look at the dosing very specifically and it took many years. And I
think it’s always a work in progress. At this point, we have essentially algorithms
based on what I call clinical profiles. What we do to help our patients is determine the
relative value of our system based on gender, age, age of onset of hair loss, rate of progression
of hair loss, degree of hair loss, other previous treatments and the responsiveness as well
as the other medical variables that are important in managing hair loss. So what we’re doing
essentially is managing hair loss. Many of our more vocal colleagues were very
dismissive and continue to be dismissive. Thankfully, in the dermatology literature,
PRP’s role in hair loss has been now well established through the publication of peer
reviewed articles. It took time and eventually, they were starting to catch up. However, what I think is a challenge that
you’re facing now as a prospective patient is that doctors are embracing this now as
a potential benefit with helping people with hair loss without having a clear plan. PRP
can stimulate hair growth. Acellular matrix can stimulate hair growth so what’s the
difference? Well, we have to think about it as a scientific point of view. Acellular matrix
exists not just for hair loss. In fact, its original purpose was for wound healing and
continues to be so. I use this material extensively in my other cosmetic procedures whether it’s
face lifting surgery, skin grafts and tissue grafts, for basically any kind of incision
when I want to expedite healing or challenging situations whether it’s reconstructive procedures.
I leverage the benefit of Acellular matrix for its ability to stimulate adult stem cells,
to enhance wound healing. I find that the combination is greater than each element on
its own. But the dosing and delivery methods is what challenged us continuously to optimize
the results for our patients. So essentially, there is no clear understanding
as to the mechanism of how these modalities help people stimulate hair growth. But in
our practice, what we have developed are algorithms to help different patients with different
clinical profiles and I look at the feasibility and the practical longevity and effectiveness
in every given patient’s clinical profile. For example, a young person or a young male
with aggressive hair loss progression and who has advanced hair loss is going to be
treated very differently than a middle aged male with slow progression, later onset and
moderate hair loss or a female with later onset and moderate hair loss. Each patient
comes with their own clinical profile. So I would say that it’s very important
to meet with a doctor and ask what is the plan. Is the plan simply to come to the office
every month for an injection or come to the office every 3 months for an injection with
no clear sense of what is the expected outcome and what is the commitment to long-term management.
I think that a lot of my colleagues are getting a more of an awakening when this one size
fits all, whether the distinction is to say we have the best PRP machine or my PRP is
better than the guy next door which is not relevant and whether this one shotgun approach
which is basically using the same formulation of PRP and Acellular matrix for every patient
is not going to yield the same results that they would expect with consistency and is
already starting to become the case. Patients are reaching out to us after they’ve had
treatments done elsewhere for a more experienced perspective. I think that it’s ultimately in your best
interest to interview the doctors and see what is their level of experience and whether
or not you can get some sense of predictability and what kind of role does this technology
play in your overall hair loss management. I emphasize to all our patients and 95% of
patients with hair loss have androgenetic alopecia, genetic pattern loss, is that hair
loss is progressive. There is no cure but there are strategies to manage hair loss:
pharmaceuticals, non-surgical as well as surgical. And the art is in maximizing the effectiveness
to get the most coverage for the longest period of time and essentially managing this hardwiring
in the DNA. So I hope that was helpful, I wish you the
best of luck and thank you for your question.

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11 Replies to “Differentiating ACell from PRP in Hair Loss Treatment, and Why a Custom Combination Works Best”

  1. I want to have a consultation but I don't live in US, do you do Skype consultation? If so how can I get a Skype consultation?

  2. hello doctor, how many sessions are recommended to obtain results? How much time do you recommend in between sessions? What is the price per session? Thank you.

  3. I am experience hair loss and hair thinning. I am 27 years. I had beautiful thick hair till a year ago. But I have been going through depression for at least 11 months now – which is probably the root cause of hair loss. I also have dandruff, which they say can be an aggravator. Specialists who inspected me say that I am in stage 2 of balding. I don't have much of a receding problem.

    Would you recommend laser treatment with some homoeopathy medicines or PRP?
    How effective are they?
    How long do they last?
    What are their pros and cons?
    Any other treatment methods?

    Waiting for your valuable feedback.

    Thank you.

  4. Can this treatment be applied in level 1 of alopecia or even in individuals without any apparent hair loss issue just for prevention? Is there a risk of getting the opposite result (hair loss) by doing so? Does this treatment get your scalp thicker to stimulate vascularisation such as the Hcell treatment?

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