Immune Dysregulation in Atopic Dermatitis

Immune Dysregulation in Atopic Dermatitis

This educational program has been developed
by Regeneron Pharmaceuticals and Sanofi Genzyme. The speakers have been compensated
for their time and effort. Th2 cells and their secreted cytokines are
central to the pathophysiology of atopic dermatitis. In particular, Th2 cells produce interleukin-4
and interleukin-13 or IL-4 and IL-13 which are
key drivers of the immune dysregulation that we see in atopic dermatitis. This brief video depicts some
of the actions of these cytokines. Note the central role of IL-4 and IL-13 in
this process. The downstream signaling from IL-4 leads to
B-lymphocyte differentiation into IgE-producing plasma
cells. Migration of IL-4 and IL-13
secreting Th2 cells into the skin allows them to continue to secrete these
cytokines and activate a variety of other cell types further amplifying the
immune response. The many effects of this signaling cascade
on the epidermis include decreased production of a number of key structural
proteins, innate immune receptors and antimicrobial peptides.

🦋Escucha a tu corazón, no te rindas, ese dolor que hoy sientes en tu interior, se irá

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