Ovarian Cancer Tumor-Stroma Proportion and Resistance to Platinum Chemotherapy

Ovarian Cancer Tumor-Stroma Proportion and Resistance to Platinum Chemotherapy


>>You’re publishing a paper in JAMA Oncology
about ovarian cancer and chemotherapy. So tell us about this paper.>>This was a very exciting study, although
it was very small, only in 24 patients. But the investigators question whether the
tumor-stroma proportion could predict those patients who didn’t respond to chemotherapy. So they divided the patients up into those
that had less than 50% tumor-stroma proportion and those that had greater than
50% tumor-stroma proportion. And they found that the tumor-stroma
proportion was really an excellent indicator of those patients who wouldn’t
respond to chemotherapy. And the beauty of the study
is you can make the diagnoses, or quantitation of tumor-stroma proportion and simple hematoxylin esosin-staining
that we do on all tumors.>>Tell us a little bit about tumor-stroma.>>Tumor stroma is the fibrous material
that really encapsulates a tumor. So often times when we think of
invasive cancer we think of it like fingers growing all through tissue. But many cancers are actually in
little balls encased by material that really prevents anything
from penetrating into the cancer. And we’ve come to realize
that having very robust stroma in your tumor can be a bad prognostic indicator.>>And how do you see this
potentially being used in the clinic?>>Potentially it would be a good
prognostic indicator for people to know at the time they are diagnosed
with ovarian cancer. We’re having so many different therapies come
into play in ovarian cancer, you might use this and then say to the patient, “We’re
going to add something to your therapy.” or “Put you right away on a clinical trial that may be using drugs that
would modulate the stroma.” So the clinical impact today
might not be immediate. But it may be a way that we can
offer the patients new treatments that they may respond to better.

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